Sexual Dimorphism in the Age of Genomics: How, When, Where

In mammals, sex chromosomes start to program autosomal gene expression and epigenetic patterns very soon after fertilization.Yet whether the resulting sex differences are perpetuated throughout development and how they connect to the sex-specific expression patterns in adult tissues is not known.There is a dearth of information on the timing and co

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Hijacking Endocytosis and Autophagy in Extracellular Vesicle Communication: Where the Inside Meets the Outside

Cars Extracellular vesicles, phospholipid bilayer-membrane vesicles of cellular origin, are emerging as nanocarriers of biological information between cells.Extracellular vesicles transport virtually all biologically active macromolecules (e.g., nucleotides, lipids, and proteins), thus eliciting phenotypic changes in recipient cells.However, we onl

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Emotion-body connection dispositions modify the insulae-midcingulate effective connectivity during anger processing.

The link between anger and bodily states is readily apparent based on the autonomic and behavioral responses elicited.In everyday life angry people react in different ways, from being agitated with an increased heart rate to remaining silent or detached.Neuroimaging evidence supports the role of mid-posterior insula and midcingulate cortex/MCC as k

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Cellular mechanotransduction of human osteoblasts in microgravity

Abstract Astronauts experience significant and rapid bone loss as a result of an extended stay in space, making the International Space Station (ISS) the perfect laboratory for studying osteoporosis due to the accelerated nature of bone loss on the ISS.This prompts the question, how does the lack of load due to zero-gravity propagate to bone-formin

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